Catching up on some news
Chelsea
(W 23rd, 28th): Chelsea stops are usually dirtier and more crowded than their eastern counterparts. They are not as bad as the times sq and herald sq stops and will have interesting people willing to talk to you, however, they usually won't be as engaging as Gramercy, Soho, or meatpacking due to the big malls and shops in that area that attract a lot of families or shopping-minded people. Nevertheless, those Chelsea stops are good for drunken nights waiting in the stations, since you will never know what to expect from the Chelsea crowd.
West Village
(W 4th): The west village would have seemed an obvious choice, however it has to be said that the W 4th st subway station is a bad place to approach people, especially women. The sheer size of the station not to mention the dirtiness, the suspicious bundle in the corner, and just the overall weirdness hanging around that station make it an unenjoyable location to meet people. Women will most certainly have their guard up, making it very difficult to approach them. Not to mention, you will be more preoccupied with the several cross-dressers, drag queens and just plain weird people that regularly pass through this station.
Meatpacking
(14th & 8th): In my opinion, the meatpacking subway station (14th & 8th on the A, C, E, & L) will have the best looking, most beautiful, and most stylish men and women of any other subway stop. Meatpacking in general is a very trendy and stylish area, filled with good restaurants, crazy clubs, and good drunken memories. The people that attend these venues are usually copies of the clubs they are attending, whether they belong to the rock & roll, the European dance, or the posh and exclusive crowd. Men and women at this location will usually have their guard down since they are on their way to go out, so approaching them will be easy. However, be warned, these men and women will want to play games, so expect a long night of flirting, partying, and drinking.